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Liquid chromatography mass spectrometry

Liquid chromatography mass spectrometry/mass spectrometry is used as a complimentary technique for the synthesis of organic and biological compounds such as proteins and peptides. This technique can be used qualitatively for the identification of unknown compounds or quantitatively for analysing the purity of a sample. The versatility of columns available for this technique mean that samples can be separated in an ionic, aqueous or even organic based environment.

Liquid chromatography mass spectrometry / mass spectrometry has the capability of separating and detecting a variety of compounds in a mixture. This equipment contains a Waters separations module 2695 combined with a Quarttro-micro unit. The separations module can be used in unison with the mass spectrometry unit or as a stand-alone mass spectrometry unit.

Examples of use

  • Pharmaceutical and biopharmaceutical samples can be analysed for amino acids, intact proteins, oligonucleotide and peptides. This can give a guide for purity and quality control. Drug testing is a common application in this area.
  • Environmental testing of pollutants and contaminants such as dioxins and furans in samples such as ground water, soils and waste water.
Fabrication step: Characterisation
Function: Bulk microscopy
Location: University of Queensland
Purpose: For separation, characterisation and analysis of organic aqueous, volatile and/or polymer materials
Material systems: Organic, inorganic, polymers and biological
Node: Queensland
Scale/volume: individual sample/system analysis
Specifications/resolution: 1. GC MS mass range 1 1050 amu; oven 40 300oC; 110 position autosampler; CI and EI sources 2. HPLC 2mL/4mL vial holder; 2mL sample loop for preparative C18 column; 20µL sample loop for analytical column; 4 line pump for gradient elution; Dual ? detect