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Flash chromatography

Flash Chromatography is a scale-up, high throughput version of column chromatography used for the purification of organic compounds. It is a complimentary tool for the synthetic organic chemist as most reactions do not go to completion and have various by-products. The technique separates compounds on the basis of the relative rates that a compound interacts with a packing material such as silica.

The Buchi flash chromatography unit has two pumps for gradient elution, a flexible arrangement for the use of multiple columns, R.I. and UV detectors for monitoring the elution of products and a fraction collection unit. The system also has a column packer to reduce packing problem and for a safer ease of use.

Examples of use:

  • Flash chromatography can be used to separate and purify products from simple or complex organic reactions such as cyclopropyl amino ketones separations from Grignard reagents.
  • Flash chromatography can be used to separate components of mixtures such as compounds extracted from coal and tar or compounds such as naringin and narirutin from citrus molasses.
Fabrication step: Characterisation
Function: Bulk microscopy
Location: University of Queensland
Purpose: High throughput column chromatography used to purify organic compounds.
Material systems: Organic and/or polymers
Node: Queensland
Scale/volume: Up to 1 20g sample loading
Specifications/resolution: Variable sized glass columns, pressure 0 to 10 bar, 0 to 100mL/min flow rates and a single pump for isocratic runs