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Rapid point of care sensor for infectious disease discrimination Return to case studies page

Sasi Kandasamy, Vic node with Biodetectors Pty Ltd and the Small Technologies Uptake Program (STUP)
Bead-based technologies are used in many applications including genetic screening, diagnostics, drug discovery and protein analysis. They allow for fast, specific, high-throughput analysis of target molecules.

The Victorian node of ANFF, the MCN, is supporting a project through device design, prototype fabrication and optical assay verification. The proposed technology of anisotropically etched pyramidal wells on silicon substrate, and its subsequent use as a template for the PDMS fluorescent bead arrays, is a simple, versatile and inexpensive method for the fabrication of high-density bead arrays. Using the micro/nano fabrication platforms available at the MCN, arrays of pyramidal wells have been patterned and fabricated to allow fluorescent bead molecules to be assembled in them.

The figure shows an SEM image of an array of fabricated pyramid wells (6um width) on a silicon master. This work will help demonstrate the potential to create high density arrays with better readout capabilities and superior signal to noise ratio than those achievable with classical microarrays.